This clinical instance reports the case of a man diagnosed with primary anorectal melanoma.
Anal melanoma is a malignant neoplasm arising from melanocytes present in the rectal squamous epithelium, and it is the third most frequent location for the melanomas, after the skin and retinal melanomas. It is a rare neoplasm with an extremely aggressive behavior, which determines that, regardless of treatment initiated, the survival of patients longer than 5-year does not exceed 5-10% of the cases in the series published.